Archives of Dermatology · 1973 · 59 citations · 9 references
MedicineDermatologyMicrobiologyDermatopathologyInnate ImmunityMedical MicrobiologyAtopic DermatitisFungal InfectionsImmunopathology Of SkinInflammatory Skin DiseasesInflammatory Skin DisordersSkin InfectionsCandida Albicans InfectionExperimental Host InfectionExperimental Infection AssaysFungal DermatosesFungal Skin DiseasesPsoriatic DiseasePustular DermatitisPustular Lesions
<i>Candida albicans</i>, applied to human skin under occlusion for 24 hours, induced a pustular dermatitis, the severity of which was proportional to the size of the inoculum. The 10<sup>5</sup>cells produced infections in 95% of the patients. Blacks were more resistant than whites, though<i>Candida</i>grew well. Mycelial forms were rare and were not a prerequisite for a take. Infections were readily induced on skin that was stripped to the glistening layer, casting doubt on the importance of anti-<i>Candida</i>serum factors. In atopic and psoriatic skin, infections only occurred when the existing microflora was eradicated.<i>Candida albicans</i>is not a secondary invader in dermatitic skin.
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