The Effect of<i>Helicobacter pylori</i>on Gastric Acid Secretion by Isolated Parietal Cells from a Guinea Pig Association with Production of Vacuolating Toxin by<i>H. pylori</i>

Abstract

The VT(+) strain of H. pylori has an inhibitory effect on gastric acid secretion, whereas the VT(-) strain does not. This inhibitory effect was not associated with the response of second messengers. It is speculated that VT produced by H. pylori has a direct action on H(+)-K+ adenosine triphosphatase in parietal cells.