Abnormal Attention Modulation of Fear Circuit Function in Pediatric Generalized Anxiety Disorder

TLDR

Considerable work implicates abnormal neural activation and disrupted attention to facial‑threat cues in adult anxiety disorders, yet no pediatric study has examined attention modulation of neural responses to threat cues. The study aimed to determine whether attention modulates amygdala and cortical responses to facial‑threat cues differently in adolescents with generalized anxiety disorder compared to healthy controls. A case‑control study at a government clinical research institute recruited 15 adolescents with GAD and 20 controls, and measured blood‑oxygen‑level‑dependent fMRI signals while participants performed a face‑emotion rating task that systematically manipulated attention. When attending to their own fear, adolescents with GAD exhibited significantly greater amygdala, ventral prefrontal, and anterior cingulate activation.

Abstract

Considerable work implicates abnormal neural activation and disrupted attention to facial-threat cues in adult anxiety disorders. However, in pediatric anxiety, no research has examined attention modulation of neural response to threat cues.To determine whether attention modulates amygdala and cortical responses to facial-threat cues differentially in adolescents with generalized anxiety disorder and in healthy adolescents.Case-control study.Government clinical research institute.Fifteen adolescents with generalized anxiety disorder and 20 controls.Blood oxygenation level-dependent signal as measured via functional magnetic resonance imaging. During imaging, participants completed a face-emotion rating task that systematically manipulated attention.While attending to their own subjective fear, patients, but not controls, showed greater activation to fearful faces than to happy faces in a distributed network including the amygdala, ventral prefrontal cortex, and anterior cingulate cortex (P<.05, small-volume corrected, for all). Right amygdala findings appeared particularly strong. Functional connectivity analyses demonstrated positive correlations among the amygdala, ventral prefrontal cortex, and anterior cingulate cortex.This is the first evidence in juveniles that generalized anxiety disorder-associated patterns of pathologic fear circuit activation are particularly evident during certain attention states. Specifically, fear circuit hyperactivation occurred in an attention state involving focus on subjectively experienced fear. These findings underscore the importance of attention and its interaction with emotion in shaping the function of the adolescent human fear circuit.