Arquivos de Neuro-Psiquiatria · 2009 · 41 citations · 11 references
MedicineMaternal HealthObstetricsHigh-risk PregnancyMaternal-fetal MedicineWomen's HealthMaternal ComplicationsMaternal Medical Complications In PregnancyMaternal Medical ConditionsMultiple Pregnancy ComplicationsPregnancyPrenatal CareAdverse Drug ExposureImmunosuppressant Drug ExposureMultiple Sclerosis PathologyNeurologic Disorders In PregnancyPharmaceutical Exposure During PregnancyPharmacoepidemiology Of PregnancyPregnancy Drug ExposureRelapse Risk During Pregnancy
PURPOSE: Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject. METHOD: Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies). RESULTS: Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature. CONCLUSION: Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.
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Rate of Pregnancy-Related Relapse in Multiple Sclerosis
Christian Confavreux, Michael Hutchinson, Martine Hours et al. · New England Journal of Medicine · 1998 · 1.6K citations · Full text
Medicine, Neurology, Obstetrics +10
Treatment of multiple sclerosis with the pregnancy hormone estriol
Nancy L. Sicotte, Stephanie M. Liva, Rochelle Klutch et al. · Annals of Neurology · 2002 · 431 citations
Life Sciences, Immunology, Neurology +15
The reproductive effects of beta interferon therapy in pregnancy
Radinka Boskovic, R. Wide, Jacob Wolpin et al. · Neurology · 2005 · 153 citations