Familial Neonatal Hypoglycemia <i>A Syndrome Resembling Foetopathia Diabetica</i>

Abstract

SUMMARY A clinical and pathologico‐anatomic syndrome resembling that occurring in offspring of diabetic and prediabetic mothers has been described in two overweight newborn sisters. Both patients had convulsions and died during the neonatal period. In one of them where blood glucose determinations were performed a marked hypoglycemia was diagnosed. Since the mother has given birth to quite normal infants between and after the diseased children and because of the fact that there is no evidence of a prediabetic state it is suggested that the syndrome has developed as a consequence of some other metabolic error. The fact that the parents are first cousins supports the supposition that the disease may be genetically determined.