Depletion of<i>SLC4A11</i>Causes Cell Death by Apoptosis in an Immortalized Human Corneal Endothelial Cell Line

Abstract

Our data suggest that the reduction of cell number with time in SLC4A11-depleted HCECs is due to an increase in cell death by apoptosis. This suggests that SLC4A11 is necessary for cell survival and may explain the pathologic corneal endothelial cell loss in endotheliopathies due to SLC4A11 mutations.