Copper‐Catalyzed Oxidative Coupling of Alkenes with Aldehydes: Direct Access to α,β‐Unsaturated Ketones

Abstract

Let's get radical: The first copper-catalyzed oxidative coupling of alkenes and aldehydes was developed. Various aldehydes were utilized as substrates to construct α,β-unsaturated ketones. A preliminary mechanistic study indicated that this reaction is likely to proceed through a single-electron transfer.