Occurrence of an activated, profibrotic pattern of gene expression in lung CD8+ T cells from scleroderma patients

Abstract

A subset of scleroderma patients at higher risk of progressive lung disease have activated, long-lived CD8+ T cells in their lungs that could promote fibrosis directly, through production of profibrotic factors such as interleukin-4 and oncostatin M, as well as indirectly, through activation of TGFbeta.