Total Synthesis and Structural Confirmation of the Marine Natural Product Dysinosin A:  A Novel Inhibitor of Thrombin and Factor VIIa

Abstract

The structure and absolute configuration of the marine antithrombotic product dysinosin A was confirmed by total synthesis. The strategy involved disconnections to three subunits, of which two were synthesized from the readily available l-glutamic acid, d-leucine, and d-mannitol. The Grubbs olefin metathesis carbocyclization reaction was utilized to prepare two intermediates.