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CYP2C19 Genetic Variants Affect Nelfinavir Pharmacokinetics and Virologic Response in HIV-1–Infected Children Receiving Highly Active Antiretroviral Therapy

DOIFull Paper Access

19

Citations

15

References

2010

Year

Akihiko Saitoh, Edmund V. Capparelli, Francesca Aweeka, Elizabeth Sarles, Kumud K. Singh, Andrea Kovács, Sandra Burchett, Andrew Wiznia, Sharon Nachman, Terence Fenton,
JAIDS Journal of Acquired Immune Deficiency Syndromes

Abstract

CYP2C19 genotypes altered nelfinavir pharmacokinetics and the virologic response to HAART in HIV-1-infected children. These findings suggest that CYP2C19 genotypes are important determinants of nelfinavir pharmacokinetics and virologic response in HIV-1-infected children.

References

YearCitations

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