Studies on the Constituents of Broussonetia Species. IV. Two New Pyrrolidinyl Piperidine Alkaloids, Broussonetines I and J, from Broussonetia kazinoki SIEB.

Abstract

Two new pyrrolidinyl piperidine alkaloids called broussonetines I and J were isolated from the branches of Broussonetia kazinoki SIEB. (Moraceae). Broussonetines I and J were formulated as (2R)-2-{(1S, 2S)-1, 2-dihydroxy-8-[(2R, 3R, 4R, 5R)-5-(2-hydroxymethyl-3, 4-dihydroxypyrrolidinyl)octyl}-1-acetylpiperidine (1) and (2R)-2-{(1S, 2S)-1, 2-dihydroxy-8-[(2R, 3R, 4R, 5R)-5-(2-hydroxymethyl-3, 4-dihydroxy-1-acetylpyrrolidinyl)]octyl}-1-acetyl-piperidine (2), respectively, by spectroscopic and chemical methods.