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Hemorheological Effects of Pentoxifylline on Disturbed Flow Behavior of Blood in Patients with Cerebrovascular Insufficiency
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1983
Year
PharmacotherapyCerebral Vascular RegulationNeurovascular DiseaseThrombosisStrokeHematologyNeurologyDisturbed Flow BehaviorClinical ChemistryBleeding DisorderPlatelet AntagonistLaboratory MedicineAtherosclerosisBlood ViscosityVascular BiologyHemorheological EffectsCerebral Blood FlowPharmacologyThrombopoiesisCardiovascular DiseaseBlood PlateletHemostasisTrental 400MedicineCerebrovascular InsufficiencyAnesthesiologyIncreased Platelet Aggregation
The influence of pentoxifylline (11-18 mg/kg orally, Trental 400) on impaired hemorheologic conditions has been investigated in a total of 73 patients with CVI. Throughout a treatment period of 4 weeks, there was a significant improvement in red cell behavior and a significant inhibition of increased platelet aggregation; moreover, a fall in plasma fibrinogen and of blood viscosity has also been observed.