Plasma Endotoxin as a Predictor of Multiple Organ Failure and Death in Systemic Meningococcal Disease

TLDR

We prospectively quantified circulating endotoxin (LOS) in 45 patients with systemic meningococcal disease to examine its relationship with organ failure and death. Higher plasma LOS (>700 ng/L) was strongly associated with severe septic shock, ARDS, renal dysfunction, and death, with fatality rising from 0 % to 86 % across LOS strata, and LOS levels declined to a 1–3 h half‑life after antibiotics, indicating that LOS measurement offers prognostic insight into SMD.

Abstract

We studied prospectively the quantitative relation of circulating endotoxin (lipooligosaccharides [LOSs]) and the development of multiple organ failure and death in 45 consecutively admitted patients with bacteriologically verified systemic meningococcal disease (SMD). A plasma LOS level of greater than 700 ng/L correlated with development of severe septic shock (P less than .0001), adult respiratory distress syndrome (P = .0035), a pathologically elevated serum creatinine level (P less than .0001), or death as a consequence of multiple organ failure (P = .0002). Initial plasma LOS levels of less than 25, 25-700, 700-10,000, and greater than 10,000 ng/L were associated with 0%, 14%, 27%, and 86% fatality, respectively. The LOS half-life after initiation of antibiotic therapy was 1-3 h. Increasing plasma LOS levels were never seen. These observations suggest that LOS quantitation using the limulus amebocyte lysate assay with a chromogenic substrate gives important progsnotic information and may provide new insight concerning pathophysiological aspects of SMD.