Edema and Congestive Heart Failure from Thiazolidone Insulin Sensitizers—Excess Sodium Reabsoption in the Collecting Duct

Abstract

Thiazolidinediones Expand Body Fluid Volume through PPARγ Stimulation of ENaC-Mediated Renal Salt Absorption Guan Y, Hao C, Cha DR, Rao R, Lu W, Kohan DE, Magnuson MA, Redha R, Zhang Y, Breyer MD. Nat Med 11: 861–867, 2005 Thiazolidones are peroxisome proliferator-activated receptor γ (PPAR