On the relationship between Ca²⁺ efflux and membrane damage during <i>t</i>‐butylhydroperoxide metabolism by liver mitochondria

Abstract

The release of Ca 2+ from rat liver mitochondria induced by t ‐butylhydroperoxide metabolism is caused by pyridine nucleotide oxidation and precedes alterations in membrane permeability which appear to result from, rather than cause, Ca 2+ release.