Pd(II)-Catalyzed Hydroxylation of Arenes with 1 atm of O₂ or Air

Abstract

Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under 1 atm of O(2) or air is achieved under nonacidic conditions. Extensive labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.