Increased Prostaglandin E2 (PGE₂) Levels in Proliferative Diabetic Retinopathy, and Correlation with VEGF and Inflammatory Cytokines

Abstract

PGE(2) levels are significantly higher in the vitreous of patients with complications from proliferative diabetic retinopathy, and correlate with IP-10 and VEGF. The results of our study suggest that PGE(2) may have a pathogenic role in diabetic retinopathy and implicates a potential therapeutic role for nonsteroidal anti-inflammatory drugs. (ClinicalTrials.gov number, NCT01609881.).