Osmoregulation of Taurine Transporter Function and Expression in Retinal Pigment Epithelial, Ganglion, and Muller Cells

Abstract

These studies provide the first evidence that hyperosmolarity regulates TauT activity and expression in RPE and that TauT is present in ganglion and Müller cells and is regulated by hypertonicity. The data are relevant to diseases such as diabetes, macular degeneration, and neurodegeneration, in which retinal cell volumes may fluctuate dramatically.