Synthesis of Some Sulfur Containing Tetrahydrobenzo[b] Thieno(Pyridines, Quinolines, Oxazines and Pyrimidines) as Possible Radioprotective and Antineoplastic Agents

Abstract

Synthesis of novel benzothienopyridines, benzothienoquinoline, benzothienoxazines and benzothienopyrimidines utilizing 2-methyl-5,6,7,8-tetrahydro-4H-3,1-benzothienoxazine-4-one are reported. The structure of these compounds were confirmed by micro-analyses, IR, 1H-NMR and mass spectrometry. Preliminary biological studies of some compounds showed a promising radioprotection and antineoplastic activities.