The Role of Nitric Oxide in Edema Formation in L-Arginine-Induced Acute Pancreatitis

Abstract

Endogenous NO is involved in the formation of pancreatic edema in Arg-induced acute pancreatitis by increasing the vascular permeability and protein extravasation. L-NAME treatment decreased the cNOS activity and edema formation but did not prevent the histologic damage in Arg-induced acute pancreatitis.