The effect of topical corticosteroids in combination with alefacept on circulating T‐cell subsets in psoriasis

Abstract

Alefacept selectively targets the CD45RO+ lymphocyte population, as well as some other subpopulations of lymphocytes. This effect is independent of the use of additional topical therapy during the first 4 weeks. The extent of the decrease, on the contrary, is dependent on the use of corticosteroids.