Metal-Free Entry to Phosphonylated Isoindoles by a Cascade of 5-<i>exo</i>-dig Cyclization, a [1,3]-Alkyl Shift, and Aromatization under Microwave Heating

Abstract

[reaction: see text] When o-ethynylbenzyl alpha-aminophosphonates are heated under microwave conditions, a rearrangement occurs which results in the formation of phosphonylated isoindoles. The rearrangement consists of a 5-exo-dig cyclization followed by a [1,3]-alkyl shift and finally aromatization.