Organic Letters · 2009 · 237 citations · 32 references
Natural SciencesChemistryCatalysisOrganic ChemistryCatalyst PreparationCatalytic MechanismsOrganic SynthesisAlkylation CatalysisAlkylation ProcessesAlkylation ReactionsChiral Catalyst DesignEnantioselective CatalysisEnantioselective SynthesisEnantioselectivity
The H8-BINOL-derived, phosphoric acid catalyzed, highly enatioselective alkylation reaction of enamides with indolyl alcohols has been described. A phosphoric acid derived from H8-BINOL enabled an asymmetric alpha-alkylation of enamides with indolyl alcohols to give beta-aryl 3-(3-indolyl)propanones in high yields (up to 96%) and with excellent enantioselectivity (up to 96% ee).
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