Structure and stability of hexadentate complexes of ligands based on AAZTA for efficient PET labelling with gallium-68

Abstract

Pre-organised tricarboxylate ligands based on 6-amino-perhydro-1,4-diazepine bind (68)Ga rapidly and selectively in acetate buffer at pH 4 to 7, forming kinetically stable complexes suitable for use in PET imaging.