Prognostic significance of CD155 mRNA expression in soft tissue sarcomas

Abstract

CD155 was initially identified as a receptor for poliovirus. Several studies have demonstrated that CD155 overexpression in cancer cells is significant in their migration, invasion, proliferation and metastasis. The objective of the present study was to investigate the correlation between <i>CD155</i> expression and the clinical aggressiveness of soft tissue tumors. The <i>CD155</i> expression levels in 43 surgically-resected soft tissue tumors were evaluated using the quantitative real-time polymerase chain reaction (PCR). The clinicopathogical factors affecting the expression levels of <i>CD155</i> mRNA were investigated and the association between the expression levels of <i>CD155</i> and patient prognosis was identified. The <i>CD155</i> expression level was not correlated with the patient gender, site of the primary tumor, tumor depth, tumor size or presence of distant metastasis at presentation, but was correlated with patient age (Fisher's exact test). The local recurrence-free survival rate for patients with a high <i>CD155</i> expression level was observed to be significantly poorer compared with that of patients with low <i>CD155</i> expression levels (P=0.0401). Moreover, a multivariate analysis indicated that a high <i>CD155</i> expression level was an independent adverse prognostic factor for local recurrence-free survival (hazard ratio, 6.369; P=0.0328). The present study therefore suggests that the expression level of <i>CD155</i> is a useful marker for predicting the local recurrence of soft tissue tumors.