Science · 1970 · 333 citations · 2 references
MedicineNeurosciencePharmacologyNeurochemistryNeuropharmacologyPsychopharmacologyDopaminergic PharmacologyDopaminergic SignalingMonoamine NeurochemistryNeurochemical PharmacologySerotonergic PharmacologySerotonergic SignalingDopamine PharmacodynamicsDopaminergic ModulationDopaminergic System EffectsSerotonergic MechanismsSerotonergic System EffectsSerotonin SynthesisSerotonin TurnoverStriatal Dopamine Function
Large doses of L-dopa given to mice produced marked increases in brain dopamine, no change in norepinephrine, and a remarkable decrease in brain serotonin. This reduction apparently results from a release or displacement, or both, of serotonin from its storage sites.
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Treatment of Parkinsonism With Levodopa
Melvin D. Yahr, Roger C. Duvoisin, M. J. Schear et al. · Archives of Neurology · 1969 · 603 citations
Medicine, Neurology, Pharmacotherapy +14