Publication | Closed Access
Strictosidine (isovincoside): the key intermediate in the biosynthesis of monoterpenoid indole alkaloids
161
Citations
0
References
1977
Year
Molecular PharmacologyBiosynthesisBioorganic ChemistryKey IntermediateBiochemistryNatural Product SynthesisMedicineMonoterpenoid Indole AlkaloidsNatural Sciences-Epimer VincosideSecondary MetaboliteNatural Product BiosynthesisPhytochemistryPharmacologyPharmaceutical ChemistryDrug DiscoveryPrevious AssumptionsMonoterpenoid Catharanthus Alkaloids
In contrast to previous assumptions the precursor of monoterpenoid Catharanthus alkaloids, which arises from the enzymatic condensation of tryptamine (I) and secologanin (II), is 3α(S)-strictosidine (isovincoside)(III) and not its 3β(R)-epimer vincoside (IV).