Lysis of Adult Ventricular Myocytes by Cells Infiltrating Rejecting Murine Cardiac Allografts

Abstract

These data demonstrate that only a small component of myocyte injury mediated by allograft-infiltrating cells can be ascribed to CTLs within the infiltrating cell population. These findings suggest that cell types associated with a delayed-type hypersensitivity response, as well as CTLs, cause myocyte injury during cardiac rejection.