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Neurologic findings in men with isolated hypogonadotropic hypogonadism
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1989
Year
FertilityGynecologySexual DisordersIsolated Hypogonadotropic HypogonadismSocial SciencesAbnormal DevelopmentNeuropathologyDisorders Of Sex DevelopmentSexual And Reproductive HealthNeurologic FindingsInfertilityAndrologySexual DysfunctionNeurologic AbnormalitiesHormonal Male ContraceptionEndocrinologySex DifferenceDevelopmental AnomalyFoot DeformityNeuroanatomyNeuroscienceCentral Nervous SystemMedicineSexual Development (Developmental Psychology)
The study examined neurologic abnormalities in 41 men with isolated hypogonadotropic hypogonadism. The cohort exhibited anosmia, hyposmia, mirror movements, ocular motor abnormalities, cerebellar dysfunction, and pes cavus foot deformity, with a higher incidence of these features in those with a family history of delayed sexual maturation, indicating a genetically linked developmental CNS abnormality.
We studied the neurologic abnormalities in 41 men with isolated hypogonadotropic hypogonadism. Findings included anosmia, hyposmia, mirror movements, ocular motor abnormalities, cerebellar dysfunction, and pes cavus foot deformity. One-third of the subjects had a family history of delayed sexual maturation. Patients with a family history of delayed sexual maturation had a significantly higher incidence of olfactory dysfunction, mirror movements, and pes cavus foot deformity. Our data suggest that isolated hypogonadotropic hypogonadism and its accompanying neurologic abnormalities may arise from a genetically linked developmental abnormality of CNS structures.