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Effects of Ethanol on Compound Action Potential and Refractory Periods of Toad Sciatic Nerve
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1976
Year
Peripheral Nerve InjuryAnesthetic MechanismRefractory PeriodsCompound Action PotentialPeripheral NervePeripheral NervesPeripheral Nervous SystemSocial SciencesRelative Refractory PeriodsNeuropharmacologyNervous SystemPharmacologyNeurophysiologyNeuroanatomyPhysiologyNeuroscienceElectrophysiologyCentral Nervous SystemToad Sciatic NerveAnesthesiaMedicine
The action of ethanol on compound action potential, refractory periods and chronaxia are analyzed in 28 isolated sciatic nerves of toads. 85 mM ethanol increases the compound action potential and decreases the refractory periods. 342 and 513 mM ehtanol decrease the compound action potential and increase the absolute and relative refractory periods. These biphasic effects are discussed in relation with changes in Na+ and K+ permeabilities and to the greater sensitivity of thin fibers to the chemicals.