Publication | Open Access

An Integrin Binding-defective Mutant of Insulin-like Growth Factor-1 (R36E/R37E IGF1) Acts as a Dominant-negative Antagonist of the IGF1 Receptor (IGF1R) and Suppresses Tumorigenesis but Still Binds to IGF1R

Signal TransductionSignaling PathwayGrowth HormoneR36e/r37e Igf1Cell-matrix InteractionSystems BiologyMedicineCell BiologyCell SignalingTumor MicroenvironmentTumor BiologyCancer GrowthIntegrin Binding-defective MutantIgf1 Receptor