Stachybotrin C and Parvisporin, Novel Neuritogenic Compounds. I. Taxonomy, Isolation, Physico-chemical and Biological Properties.

Abstract

Stachybotrin C and parvisporin, novel neuritogenic compounds, were isolated from the culture broth of Stachybotrys parvispora F4708. Stachybotrin C induced significant neurite outgrowth in PC12 cells and showed cell survival activity in the primary culture of cerebral cortical neurons. Parvisporin demonstrated only weak neuritogenic activity.