TGF-β1 and TSC-22 Gene Polymorphisms and Susceptibility to Microvascular Complications in Type 2 Diabetes

Abstract

Our data suggest the association of TGF-beta T869C gene polymorphism with an increased risk of nephropathy and retinopathy in type 2 diabetes patients. It interacts with the TSC-22 gene involved in the TGF-beta signaling pathway, promoting the development of diabetic nephropathy.