Synthesis of 5-(3-Hydroxypropyl)-7-methoxy-2-(3‘-methoxy-4‘-hydroxyphenyl)-3- benzo[<i>b</i>]furancarbaldehyde, a Novel Adenosine A₁Receptor Ligand from the Root of<i>Salvia miltiorrhiza</i>

Abstract

A novel adenosine A 1 receptor ligand, 5-(3-hydroxypropyl)-7-methoxy-2-(3‘-methoxy-4‘-hydroxyphenyl)-3-benzo[ b ]furancarbaldehyde ( 1 ), is a constituent of the roots of Salvia miltiorrhiza . Through biomimetic considerations, methyl ferulate was used as starting material for an eight-step synthesis of 1 .