Noyori's Ts‐DPEN Ligand: Simple yet Effective Catalyst for the Highly Enantioselective Michael Addition of Acetone to Nitroalkenes

Abstract

Abstract Highly enantioselective Michael addition of acetone to a variety of nitroalkenes promoted by simple chiral primary amine bifunctional catalysts (e.g., Noyori's Ts‐DPEN ligand) together with terephthalic acid in excellent yields (84–99 %) and enantioselectivities (93–98 % ee ) is reported.