Severe Acute Respiratory Syndrome: Radiographic Appearances and Pattern of Progression in 138 Patients

TLDR

To retrospectively evaluate the radiographic appearances and pattern of progression of severe acute respiratory syndrome (SARS). Chest radiographs were obtained at presentation and during treatment in 138 confirmed SARS patients and assessed for pulmonary parenchymal abnormalities, distribution, extent, and serial progression. Initial chest radiographs were abnormal in 78 % of patients, showing air‑space opacity predominantly in the lower and right lung zones and peripheral distribution; unifocal involvement was most common, with no cavitation, lymphadenopathy, or pleural effusion, and four distinct progression patterns were identified—type 1 (deterioration to peak then improvement) in 70 %, type 2 (fluctuating) 17 %, type 3 (static) 7 %, and type 4 (progressive deterioration) 5 %—with most patients progressing from focal to multifocal or bilateral disease.

Abstract

To retrospectively evaluate the radiographic appearances and pattern of progression of severe acute respiratory syndrome (SARS).Chest radiographs obtained at clinical presentation and during treatment in 138 patients with confirmed SARS (66 men, 72 women; mean age, 39 years; age range, 20-83 years) were assessed. Radiographic appearances of pulmonary parenchymal abnormality, distribution, and extent of involvement on initial chest radiographs were documented. Recognizable patterns of radiographic progression were determined by comparing the overall mean percentage of lung involvement for each patient on serial radiographs.Initial chest radiographs were abnormal in 108 of 138 (78.3%) patients and showed air-space opacity. Lower lung zone (70 of 108, 64.8%) and right lung (82 of 108, 75.9%) were more commonly involved. In most patients, peripheral lung involvement was more common (81 of 108, 75.0%). Unifocal involvement (59 of 108, 54.6%) was more common than multifocal or bilateral involvement. No cavitation, lymphadenopathy, or pleural effusion was demonstrated. Four patterns of radiographic progression were recognized: type 1 (initial radiographic deterioration to peak level followed by radiographic improvement) in 97 of 138 patients (70.3%), type 2 (fluctuating radiographic changes) in 24 patients (17.4%), type 3 (static radiographic appearance) in 10 patients (7.3%), and type 4 (progressive radiographic deterioration) in seven patients (5.1%). Initial focal air-space opacity in 44 of 59 patients (74.6%) progressed to unilateral multifocal or bilateral involvement during treatment.Predominant peripheral location; common progression pattern from unilateral focal air-space opacity to unilateral multifocal or bilateral involvement during treatment; and lack of cavitation, lymphadenopathy, and pleural effusion are the more distinctive radiographic findings of SARS.