The Influence of CpG Motifs on a Protein or DNA-Based Th2-Type Immune Response against Major Pollen Allergens Bet v 1a, Phl p 2 and <i>Escherichia coli</i>-Derived β-Galactosidase

Abstract

The effect of CpG motifs in vivo depends on a variety of parameters like the nature of the antigen and the immunization modality. Furthermore, our studies indicate that a combination of CpG + DNA immunization may be more effective in antagonizing Th2 responses than the combination of CpG + protein immunization.