Hyaluronic acid and chondrogenesis of murine bone marrow mesenchymal stem cells in chitosan sponges

Abstract

High-molecular-weight HA supplementation in culture medium had a dose-dependent effect on matrix production and thus chondrogenic differentiation of MSCs cultured on chitosan sponges. The addition of HA in the surrounding fluid during chondrogenesis should improve cartilage production and may be useful for producing engineered cartilage tissues.