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Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin in the Syrian golden hamster

DOI

73

Citations

0

References

1988

Year

Mahendra S. Rao, V. Subbarao, Jada D. Prasad, D. G. Scarpelli
Carcinogenesis

Abstract

The carcinogenic potential of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in Syrian golden hamsters, at different dose levels. Twenty-one percent of the hamsters that received a total of 600 micrograms/kg body weight of TCDD either by the s.c. or i.p. route developed squamous cell carcinomas of the skin of facial region within 12-13 months from the beginning of the experiment. Neoplasms were not observed in any other organs. These studies suggest that TCDD may be a complete carcinogen in hamsters, the species most resistant to the toxic effect of this compound.