Concepedia

In vitro P-glycoprotein affinity for atypical and conventional antipsychotics

David W. Boulton, C. Lindsay DeVane, Heidi L. Liston, John S. Markowitz

Life Sciences · 2002 · 259 citations · 10 references

DOI

Concepts

References

10

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

, , +15

Increased drug delivery to the brain by P-glycoprotein inhibition

Abu Sadeque · Clinical Pharmacology & Therapeutics · 2000 · 423 citations

, , +13

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery

Leslie Z. Benet, Takashi Izumi, Yuanchao Zhang et al. · Journal of Controlled Release · 1999 · 294 citations

, , +16

Pharmacokinetics and tissue distribution of olanzapine in rats

Manickam Aravagiri, Yaroslav Teper, Stephen R. Marder · Biopharmaceutics & Drug Disposition · 1999 · 199 citations

, , +16

Oral bioavailability of digoxin is enhanced by talinolol: Evidence for involvement of intestinal P-glycoprotein

Kristin Westphal · Clinical Pharmacology & Therapeutics · 2000 · 176 citations

, , +17