Loss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C   phosphorylation

Abstract

The cardioprotective effect of IPC is lost in female hearts with chronic oestrogen withdrawal and this is due, at least in part, to impaired translocation and phosphorylation of PKCepsilon. Selective activation of PKCepsilon-mediated signalling can fully restore the IPC effect in a manner analogous to oestrogen replacement.