Severe Steatosis Increases Hepatocellular Injury and Impairs Liver Regeneration in a Rat Model of Partial Hepatectomy

Abstract

Steatosis with prominent inflammation impaired liver regeneration probably because of increased hepatocellular lipid peroxidation and damage in concert with Kupffer cell-mediated proinflammatory responses. These results suggest an increased risk of performing extensive liver resection in the presence of severe steatosis.