Viable Fibroblast Matrix Patch Induces Angiogenesis and Increases Myocardial Blood Flow in Heart Failure After Myocardial Infarction

Abstract

The 3DFC functions as a cell delivery device providing matrix support for resident cell survival and integration into the heart. The imbedded fibroblasts of the 3DFC release a complex blend of cardioactive cytokines promoting increases in microvessel density and anterior wall blood flow but does not improve ejection fraction or alter LV remodeling.