The Journal of Clinical Psychiatry · 2004 · 41 citations · 0 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyPsychopharmacologyPsychotherapySedation ManagementSedative PharmacologyAdditive EffectsModafinil PharmacologyModafinil TherapySedation Dose AdjustmentSedation MinimizationSedation Supportive TherapySedation-related Adverse EffectsSedative Additive Effects
Article AbstractBecause this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text.Sir: When used concomitantly, medications having the potential to cause sedation may produce additive sedative effects. Certainly this may have occurred in our patients2 as a result of divalproex administration. Importantly, however, at the time of modafinil initiation our patients were stable and sedation was their primary complaint. Thus, regardless of serum levels, it would not have been prudent to decrease the dosage of divalproex in order to minimize the existing sedation at the risk of symptom decompensation.