Excess Blood-group Substance A in Serum of Patient Dying with Carcinoma of Stomach

Abstract

biochemical evidence goes even further in suggesting that there is no difference in the total amounts of blood group substance between all duodenal ulcer patients and controls. It would seem, therefore, that if the association between group 0, non-secretion, and duodenal ulcer is causal (but not due to a pleotropic effect of the genes) the most probable explanation can be found in the differences between the antigenic properties of the A, B, H, and Lewis group-specific substances, and this would imply that there is an immunological factor in the pathogenesis of duodenal ulcer (see Clarke et al., 1957).