Determination of mitomycin C, 2,7-diaminomitosene, 1,2-cis- and 1,2-trans-1-hydroxy-2,7-diaminomitosene in tumour tissue by high-performance liquid chromatography

Mitomycins and Porfiromycin: Chemical Mechanism of Activation and Cross-linking of DNA

V. N. Iyer, Waclaw Szybalski · Science · 1964 · 569 citations

Pharmacy, Chemical Biology, Molecular Biology +16

Bioactivation as a Model for Drug Design Bioreductive Alkylation

Harold W. Moore · Science · 1977 · 433 citations

Medicine, Pharmacology, Drug Design +5

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

David Siegel, N W Gibson, Peter C. Preusch et al. · PubMed · 1990 · 225 citations

Medicine, Molecular Biology, Oncology +15

Reductive activation of mitomycin C and mitomycin C metabolites catalyzed by NADPH-cytochrome P-450 reductase and xanthine oxidase.

Shengze Pan, Paul A. Andrews, Constance J. Glover et al. · Journal of Biological Chemistry · 1984 · 214 citations · Full text

Life Sciences, Biochemistry, Cellular Metabolism +14

Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.

Paul R. Hoban, Michael I. Walton, Craig Robson et al. · PubMed · 1990 · 87 citations

Medicine, Biochemistry, Pharmacology +16