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A simple regioselective synthesis of ethyl 1,5‐diarylpyrazole‐3‐carboxylates
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1989
Year
EngineeringSimple Regioselective SynthesisArylphenylhydrazine HydrochloridesOrganic ChemistryNew ProceduresChemistryRegioselective PreparationAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
Abstract Improved procedures for the regioselective preparation of ethyl 1,5‐diarylpyrazole‐3‐carboxylates are described. The new procedures utilize readily prepared lithium aroylpyruvate intermediates which, when combined with arylphenylhydrazine hydrochlorides form 1,5‐diarylpyrazole‐3‐carboxylates regioselectively in good to excellent yield.