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Design and Development of Amphotericin B Bearing Polycaprolactone Microparticles for Macrophage Targeting
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2011
Year
EngineeringAntiparasitic AgentImmunologyAntileishmanial EfficacyBiomedical EngineeringVisceral LeishmaniasisNanomedicineMedicinal ChemistryAmphotericin BDrug Delivery SystemMacrophage TargetingCell-based Drug DeliveryPcl MicroparticlesMicro-encapsulationPharmacologyDrug TargetingPolymer-drug ConjugateNano-drug DeliveryMedicineDrug Discovery
Antileishmanial efficacy of Amphotericin B bearing polycaprolactone (PCL) microparticles was investigated. The microparticles were prepared, optimized and subjected to in vitro characterization for shape (spherically structured), particle size (9.83 +/- 1.12 microm), entrapment efficiency (43.54 +/- 3.98%) and in vitro drug release. The study revealed that PCL microparticles bearing Amphotericin B can be effectively used to target leishmanial parasites residing in macrophages.