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Detection of Autoantibodies against NMDA-Type Glutamate Receptor in a Patient with Recurrent Optic Neuritis and Transient Cerebral Lesions
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2007
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Transient Cerebral LesionsNeurological DisorderClinical NeurologyOptic NerveSocial SciencesNeurobiology Of DiseaseJapanese GirlNeurologyNeuropathologyNeuroimmunologyOphthalmologyOptic NeuropathyNmda-type Glutamate ReceptorsNmda-type Glutamate ReceptorRecurrent Optic NeuritisNeuroscienceGlaucomaMultiple SclerosisCentral Nervous SystemMedicine
We describe the case of a Japanese girl with recurrent optic neuritis and transient cerebral lesions. Antibodies against N-methyl-d-aspartate (NMDA)-type glutamate receptors were detected in both serum and cerebrospinal fluid. Results of this case study suggest that the development of autoantibodies against NMDA-type glutamate receptors may play a role in the pathogenesis of central nervous system demyelinating diseases.