Impaired inotropic response to ??1 but not to ??-adrenoceptor stimulation in isolated hearts from spontaneously hypertensive rats

Abstract

Long-standing hypertension leads to an impaired response of the isolated heart to alpha 1-adrenoceptor stimulation, without changes in alpha 1-receptor density or affinity. It seems likely that changes in postreceptor events are responsible for the impaired inotropic response to alpha 1-adrenoceptor agonists in hearts from SHR.